GLP-1 Side Effect Probability Tool
View the likelihood of common side effects based on clinical trial data for each compound and dose tier.
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Semaglutide - Maintenance Dose
Smaller meals, slower eating, lower-fat foods, and delayed escalation if needed.
Hydration and provider review if persistent or severe.
Call a clinician for repeated vomiting or dehydration symptoms.
Fluids, fiber as tolerated, movement, and clinician-approved stool softeners.
Track severity and seek care for intense or persistent pain.
Hydration, regular meals, and blood-pressure review if recurring.
Check calorie, protein, fluid, and sleep adequacy.
Avoid large late meals and discuss reflux options with a clinician.
Prioritize protein and fluids early in the day.
Review hydration, blood pressure, and glucose if applicable.
Reduce trigger foods during escalation weeks.
Rotate sites and avoid irritated areas.
All Dose Tiers Comparison
| Side Effect | Starting | Maintenance | Max |
|---|---|---|---|
| Nausea | 20% | 44% | 44% |
| Diarrhea | 15% | 30% | 32% |
| Vomiting | 8% | 24% | 25% |
| Constipation | 12% | 24% | 24% |
| Abdominal pain | 8% | 20% | 20% |
| Headache | 10% | 14% | 14% |
| Fatigue | 5% | 11% | 11% |
| Dyspepsia | 4% | 9% | 9% |
| Decreased appetite | 8% | 9% | 9% |
| Dizziness | 3% | 8% | 8% |
| Flatulence | 4% | 7% | 7% |
| Injection site reaction | 3% | 4% | 4% |
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Medical Disclaimer: Side effect probabilities shown are from published clinical trial data and represent averages across study populations. Your individual experience may differ. Most GI side effects are mild to moderate and decrease over time with proper titration. Consult your healthcare provider about any side effects you experience.