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MK-677 (Ibutamoren)
Oral growth hormone secretagogue for sustained GH elevation
25mg/mL (30mL) | 25mg/mL
About MK-677 (Ibutamoren)
MK-677 (Ibutamoren) is unique among growth hormone secretagogues because it is orally bioavailable, eliminating the need for injection. It functions as a ghrelin receptor agonist, stimulating the pituitary to release growth hormone in a sustained manner.
Clinical studies have demonstrated that MK-677 increases GH secretion and IGF-1 levels to those of healthy young adults, even in elderly populations. A landmark 2-year study showed sustained increases in GH and IGF-1 without tolerance development, suggesting long-term viability.
MK-677 also significantly improves sleep architecture, particularly increasing Stage 4 (deep) sleep duration by up to 50%. This deep sleep enhancement further promotes natural GH release, creating a positive feedback loop for recovery and regeneration.
Key Benefits
Published Research
2-year RCT in elderly (N=65) showed sustained IGF-1 elevation to young-adult levels without tolerance. Increased fat-free mass by 1.6kg. 50% increase in REM and Stage IV sleep. No significant adverse effects on glucose tolerance at 12.5mg dose.
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